What Does High Globulin Mean. If this ratio changes to an extreme level, it can cause a number of health concerns. Hypergammaglobulinemia is an uncommon condition characterized by elevated levels of immunoglobulins in your blood.

But if your globulin is lesser or greater than the above values, then there may be some problem in your body. High globulin levels may also indicate certain types of cancer, such as multiple myeloma, hodgkin’s disease, or malignant lymphoma. A low ratio can be a sign of autoimmune disorders, poor kidney function, or liver disease.